Makoto Kaneko

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Current Research Topics
Cell Exercise
RBC Deformability Checker
Cell Pinball
Cell Fatigue Test
High-Speed Cell Manipulation
100mPa Cell Manipulation
Cell Tracking
On-Chip Catch-Load-Launch
On-Chip Blood Separation
On-Chip Pressure Sensor
Links
How to Contact Me
List of Achievements
Innovative Biomarker and Applications
Kaneko Higashimori Laboratory
Department of Mechanical Engineering
Graduate School of Information Engineering
Osaka University



Current Research Topics


Cell Exercise

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Cell Exercise is a new approach of cell culture using periodic pressure. Preliminary results show a stronger structure in an exercised cell sheet.
Reference
  1. U. Yokoyama, Y. Tonooka, R. Koretake, T. Akimoto, Y. Gonda, J. Saito, M. Umemura, T.Fujita, S. Sakuma, F. Arai, M. Kaneko and Y. Ishikawa, Arterial graft with elastic layer structure grown from cells, Scientific Reports, vol.7, 43134, 2017. (IF=5.228)

RBC Deformability Checker

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The RBC deformability checker is developed for evaluating the risk of storke and other RBC-related diseases.
Reference
  1. 赤血球の硬さ迅速判定=心臓病リスク評価も-阪大, JIJI News, 2016/10/21.
  2. 赤血球の硬さで病気リスク判断、阪大が手法開発, YOMIURI News, 2016/10/20.
  3. C. Tsai, J. Tanaka, M. Kaneko, M. Horade, H. Ito, T. Taniguchi, T. Ohtani and Y. Sakata: An On-Chip RBC Deformability Checker Significantly Improves Velocity-Deformation Correlation, Micromachines, vol.7, 176, 2016. (SCI, IF=1.295)
  4. C. Tsai, S. Sakuma, F. Arai and M. Kaneko: A New Dimensionless Index for Evaluating Cell Stiffness-based Deformability in Microchannel, IEEE Transactions on Biomedical Engineering, vol.61, no.4, pp1187-1195, 2014. (SCI, IF=2.233)
  5. Y. Hirose, K. Tadakuma, M. Higashimori, T. Arai, M. Kaneko, R. Iitsuka, Y. Yamanishi and F. Arai: A New Stiffness Evaluation toward High Speed Cell Sorter, IEEE International Conference on Robotics and Automation (ICRA2010), (Anchorage, USA, 2010.5), pp4113-4118.

Cell Pinball

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Surprising cell behavior is observed and analysis for the physics behind it.
Reference
  1. R. Murakami, C. Tsai, M. Kaneko, S. Sakuma and F. Arai: Cell Pinball: Phenomenon and Mechanism of Inertia-Like Cell Motion in a Microfluidic Channel, Lab on a Chip, vol.15, pp3307-3313, 2015 (SCI, IF=6.115)  Highlighted on Lab on a Chip blog
  2. R. Murakami, M. Kaneko, S. Sakuma, and F. Arai: "Cell pinball" : what is the physics?, IEEE International Conference on Micro Electro Mechanical Systems (MEMS), (Estoril, Portugal, 2015.01), pp. 431-434, (2015).

Cell Fatigue Test

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Cells gradually lose their deformability after continuous passing the narrow throat.
Reference
  1. S. Sakuma, K. Kuroda, C. Tsai, W. Fukui, F. Arai and M. Kaneko: Red Blood Cell Fatigue Evaluation based on the Close-encountering Point between Extensibility and Recoverability, Lab on a Chip, vol.14, no.6, pp1135-1141, 2014 (SCI, IF=6.115)
  2. K. Kuroda, W. Fukui, M. Kaneko, S. Sakuma, and F. Arai: A new index of cell fatigue under reciprocative stress test, The 17th International Conference on Miniaturized System for Chemistry and Life Sciences (MicroTAS2013), (Freiburg, GERMANY, 2013.10), pp.371-373

High-Speed Cell Manipulation

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By high-speed actuator and vision system, 130 Hz cell manipulation is achieved.
Reference
  1. T. Monzawa, M. Kaneko, C. Tsai, S. Sakuma and F. Arai: On-Chip Actuation Transmitter for Enhancing the Dynamic Response of Cell Manipulation using a Macro-scale Pump, Biomicrofluidics, vol.9, no.1, 014114, 2015 (SCI, IF=3.771)
  2. S. Sakuma, K. Kuroda, F. Arai, T. Taniguchi, T. Ohtani, Y. Sakata and M. Kaneko: High resolution cell positioning based on a flow reduction mechanism for enhancing deformability mapping, Micromachines, 5(4), pp. 1188-1201, 2014.

100mPa Cell Manipulation

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A gravity-based pressure control system is developed for precise cell manipulation up to 100mPa.
Reference
  1. K. Mizoue, M. H. Phan, C. Tsai, M. Kaneko, J. Kang and W. K. Chung: Gravity-Based Precise Cell Manipulation System Enhanced by In-Phase Mechanism, Micromachines, vol.7, 116, 2016. (SCI, IF=1.295)

Cell Tracking

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By image processing algorithms, cell behaviors, such as trajectories and deformation, can be automatically determined.
Reference
  1. C. Tsai, S. Sakuma, F. Arai, T. Taniguchi, T. Ohtani, Y. Sakata and M. Kaneko: Geometrical Alignment for Improving Cell Evaluation in a Microchannel with Application on Multiple Myeloma Red Blood Cells, RSC Advances, vol.4, no.85, pp45050-45058, 2014 (SCI, IF=3.840)
  2. C. Tsai, S. Sakuma, F. Arai and M. Kaneko: A New Dimensionless Index for Evaluating Cell Stiffness-based Deformability in Microchannel, IEEE Transactions on Biomedical Engineering, vol.61, no.4, pp1187-1195, 2014 (SCI, IF=2.233)
  3. S. Yoshikawa, C. Tsai, S. Sakuma, F. Arai and M. Kaneko*: Realtime Cell Tracking in a Microchannel, The 10th International Conference on Ubiquitous Robots and Ambient Intelligence (URAI2013), (Jeju, Korea, 2013.11), pp144-147.

On-Chip Catch-Load-Launch

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Cell viscoelastic properties are evaluated by applying different duration of loading time to test cells.
Reference
  1. R. Murakami, C. Tsai, H. Ito, M. Tanaka, S. Sakuma, F. Arai and M. Kaneko: Catch, Load and Launch toward On-Chip Active Cell Evaluation, IEEE International Conference on Robotics and Automation (ICRA2016), (Stockholm, Sweden, 2016.5), pp1713-1718.

On-Chip Blood Separation

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By physics of fluid inside a microchannel, blood can be spontaneously separated into plasm and blood cells.
Reference
  1. T. Monzawa, M. Kaneko, C. Tsai, S. Sakuma and F. Arai: On-Chip Actuation Transmitter for Enhancing the Dynamic Response of Cell Manipulation using a Macro-scale Pump, Biomicrofluidics, vol.9, no.1, 014114, 2015 (SCI, IF=3.771)
  2. T. Monzawa, S. Sakuma, F. Arai, and M. Kaneko:Red blood cell deformability checker with water/plasma pressure transmitter, The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2014), (San Antonio, USA, 2014.10), pp.1181-1183.

On-Chip Pressure Sensor

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A novel on-chip pressure sensor is developed for measuring local pressure inside a microchannel where commercial sensors are difficult to embedded.
Reference
  1. C. Tsai and M. Kaneko: On-Chip Pressure Sensor Using Single-Layer Concentric Chambers, Biomicrofluidics, vol.10, 024116, 2016 (SCI, IF=3.771).
  2. C. Tsai and M. Kaneko: On-Chip Micro Manometer, the 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS15), (Gyeongju, Korea, 2015.10), pp1879-1881.
  3. C. Tsai, T. Nakamura and M. Kaneko: An On-Chip, Electricity-Free and Single-Layer Pressure Sensor for Microfluidic Applications, IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS2015), (Hamburg, Germany, 2015.9-10), pp165-170.

My Biography

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Makoto Kaneko received MS and Ph.D in Mechanical Engineering from Tokyo University in 1978 and 1981. From 1981 to 1990 he was a researcher at the Mechanical Engineering Laboratory (MEL), Ministry of International Trade and Industry (MITI), Tsukuba Science City. From 1988 to 1989, he was a Post-Doctoral Fellow at Technical University of Darmstadt, Germany, where he joined a space robotics project. From 1990 to 1993, he was an Associate Professor with Computer Science and System Engineering at Kyushu Institute of Technology. From November 1991 to January 1992, he got an Invited Professorship at Technical University of Darmstadt, Germany. From October 1993 to September 2006, he was a Professor of Industrial Engineering Department at Hiroshima University. Since October 2006, he has been a Professor of Department of Mechanical Engineering at Osaka University. His research interests include tactile-based active sensing, grasping strategy, legged locomotion, sensor applications, and welfare robotics. He served as a Technical Editor of IEEE Transactions on Robotics and Automation during 1990 through 1994. He is currently the Director of the Hyper Human Research Project Center. He has been a program committee member for IEEE International Conference on Intelligent Robots and Systems since 1991. He worked as a program committee member for 1995, 1996, 1998, 1999, and 2000 IEEE International Conference on Robotics and Automation. He also worked as a program chairman for the 1998 International Conference on Advanced Mechatronics and a program co-chairman for the 1999 IEEE International Conference on Intelligent Robots and Systems. Dr. Kaneko is a member of the IEEE Robotics and Automation Society, the IEEE Systems, Man, and Cybernetics Society, and the IEEE Industrial Electronics Society. He is also a member of Japan Society of Mechanical Engineers, Robotics Society of Japan, and Japanese Society of Instrumentation and Control Engineers. He was a Vice President of IEEE Robotics and Automation Society during 2004 through 2005.



Awards

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1983: The Outstanding Young Engineer Award from the Japan Society of Mechanical Engineers
1994: The Outstanding Paper Award from the Robotics Society of Japan
1996: The Outstanding Paper Award from the Society for Instrument and Control Engineers
1997: The Humboldt Research Award from Humboldt Foundation
2000: IEEE ICRA The Best Manipulation Paper Award
2000: The Robotics and Mechatronics Award from the R&M Division of the Japan Society of Mechanical Engineers
2001: IEEE Int.Symp. on Assembly and Task Planning, The Outstanding Paper Award
2001: The Certificate of ROBOMEC from the R&D Division of the Japan Society of Mechanical Engineers
2002: The Outstanding Paper Award from the Society for Instrument and Control Engineers
2003: IEEE ICRA The Best Conference Paper Award, Finalists
2003: The Education Award of the Japan Society of Mechanical Engineers
2004: The Certificate of ROBOMEC from the R&D Division of the Japan Society of Mechanical Engineers
2004: The Japan Society of Computer Aided Surgery, The Best Conference Paper Award
2004: IEEE RAS 2003 King-Sun Fu Memorial Best Transactions Paper Award
2005: The Certificate of ROBOMEC from the R&D Division of the Japan Society of Mechanical Engineers
2005: IEEE Int. Workshop on Advanced Robotics and its Social Impacts (ARSO'05), The Distinguished Presentation Award
2005: IEEE Int. Conf. on Information Acquisition, The Best Conference Paper Award
2006: The Best Paper Award of the 11th Robotics Symposia from RSJ, JSME Robomec, and SICE
2007: The Best Paper Award from the Robotics Society of Japan
2008: The Outstanding Paper Award from the Society for Instrument and Control Engineers
2008: Award for Excellence in Physical Sciences & Mathematics,Springer Handbook of Robotics
2008: SICE Transaction Award
2009: SICE Transaction Award
2010: SICE SI department Research Award
2011: IEEE Int. Symp. on Micro-NanoMechatronics and Human Science, The Best Paper Award
2012: IEEE Int. Conf. on Mechatronics and Automation, The Best Paper Award in Automation.
2013: Japan Society of Mechanical Engineers Robotics mechatronics department Robomec awards
2013: SICE Transaction Award
2014: The Best Paper Award from the Robotics Society of Japan
2014: IEEE Int. Symp. on Micro-NanoMechatronics and Human Science, The Best Paper Award
2015: The Best Paper Award of the 20th Robotics Symposia from RSJ, JSME Robomec, and SICE
2015: The Robotics and Mechatronics Contribution Award from the R&M Division of the Japan Society of Mechanical Engineers.
2015: IEEE Int. Conf. on Mechatronics and Automation, The Toshio Fukuda Award.
2016: The Certificate of the Best Robomec Journal Paper from the R&M Division of the Japan Society of Mechanical Engineers.
2016: The Outstanding Paper Award from the Society for Instrument and Control Engineers.
2017: The Award of the Japan Society of Mechanical Engineers (Technology Achievement)




Grade

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2003: Fellow of the Japan Society of Mechanical Engineers
2006: IEEE Fellow
2009: Fellow of Robotics Society of Japan
2013: Honorary Doctor of Darmstadt University of Technology
2014: Professor Emeritus of Hiroshima University
2014: SICE Fellow




Kaneko-Higashimori Laboratory, Osaka University
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