Recent Works    Brief Bio.    Contact    Publications   Grants and Awards    Activities   



Chia-Hung Dylan Tsai, Ph.D.

Specially-Appointed Associate Professor (特任講師)
Kaneko-Higashimori Lab.
Department of Mechanical Engineering
Graduate School of Engineering, Osaka University




Recent Works  to top

Catch-Load-Launch Cell Test

Geometrical Alignment of Cells

High-Speed Cell Manipulation

 

On-Chip Pressure Sensor

RBC Deformability Checker

Cell Deformability Evaluation

 

Cell Pinball

100mPa Cell Manipulation

RBC during Long-standing Load




Brief Biography  to top

Education

2010: Ph.D. in Mechanical Engineering, State University of New York (SUNY) at Stony Brook, USA (overview, dissertation )
2002: B.Eng. in Bio-industrial Mechatronics Engineering, National Taiwan University, Taiwan


Work Experience

2016/04-Present: Specially Appointed Associate Professor in Kaneko-Higashimori Laboratory, Osaka University, Osaka, Japan
2015/05-Present: Associate Editor for Robotics and Automation Letters, IEEE
2015/02-Present: Editor for ROBOMECH Journal, Springer
2011/10-2016/03: Specially Appointed Researcher in Kaneko-Higashimori Laboratory, Osaka University, Osaka, Japan
2011/01-2011/08: Instructor in the Department of Engineering, Physics and Technologies, Nassau Community College, SUNY, USA
2011/06-2011/08: Consultant in Pliant Energy System LLC, New York, USA
2007/06-2010/12: Research Assistant in the Department of Mechanical Engineering, Stony Brook University, SUNY, USA
2006/09-2007/05: Teaching Assistant in the Department of Mechanical Engineering, Stony Brook University, SUNY, USA
2004/03-2006/08: Specialist, Assistant Supervisor, FAE in Chu-Chang Rubber, MOBIJET Tech., ARQUES Tech. Co. Ltd, Taiwan
2002/08-2004/03: Military Police in Taiwan Armed Forces, Taiwan


Area of Interest

Lab on a chip, biomedical applications, contact modeling, robotic grasping/manipulation, viscoelasticity


Contact  to top

Chia-Hung Dylan Tsai
2-1 Yamadaoka, Osaka University
Suita, Osaka, Japan 565-0871
E-Mail:
TEL: +81-6-6879-7333
FAX:+81-6-6879-4185
ORCID: 0000-0002-8840-3984


Publications  to top


Book/Chapter:
  1. C. D. Tsai, M. Kaneko: 浮遊細胞の力学的指標の高速計測 (High-Speed Evaluation of Cell Mechanics), Corona Publishing Co., LTD, 細胞の特性計測・操作と応用 (Evaluation, Manipulation and Applications of Cells), Chap.1.2, pp16-30, 2016 (ISBN:978-4-339-07261-7) (in Japanese, 日本語link
  2. C. D. Tsai, S. Sakuma, F. Arai and M. Kaneko: Dimensionless Evaluation of Cell Deformability with High Resolution Positioning in a Microchannel, Springer, Hyper Bio Assembler for 3D Cellular Systems, Chap.2, pp23-42, 2015 (ISBN 978-4-431-55297-0)  link

Journal Publications:    *corresponding author
  1. M. Horade, C. D. Tsai*, H. Ito and M. Kaneko: Red Blood Cell Responses during a Long-Standing Load in a Microfluidic Constriction, Micromachines, vol.8, 100, 2017. (SCI, IF=1.833) link  
  2. K. Mizoue, K. Teramura, C. D. Tsai*, and M. Kaneko: Transfer Function of Macro-Micro Manipulation on a PDMS Microfluidic Chip, Micromachines, vol.8, 80, 2017. (SCI, IF=1.833) link  
  3. H. Ito, R. Murakami, S. Sakuma, C. D. Tsai, T. Gutsmann, K. Brandenburg, J. Poschl, F. Arai, M. Kaneko*, and M Tanaka*: Mechanical diagnosis of human erythrocytes by ultra-high speed manipulation unraveled critical time window for global cytoskeletal remodeling, Scientific Reports, vol.7, 43134, 2017. (SCI, IF=4.259) link, 日本経済新聞  
  4. C. D. Tsai*, J. Tanaka, M. Kaneko, M. Horade, H. Ito, T. Taniguchi, T. Ohtani and Y. Sakata: An On-Chip RBC Deformability Checker Significantly Improves Velocity-Deformation Correlation, Micromachines, vol.7, 176, 2016. (SCI, IF=1.833) link, 読売新聞, 時事通信,
  5. K. Mizoue, M. H. Phan, C. D. Tsai*, M. Kaneko, J. Kang and W. K. Chung: Gravity-Based Precise Cell Manipulation System Enhanced by In-Phase Mechanism, Micromachines, vol.7, 116, 2016 (SCI, IF=1.833) link
  6. C. D. Tsai* and M. Kaneko: On-chip pressure sensor using single-layer concentric chambers, Biomicrofluidics, vol.10, 024116, 2016 (SCI, IF=2.535)  Highlighted on Biomicrofluidics Facebook link
  7. R. Murakami, C. D. Tsai*, M. Kaneko, S. Sakuma and F. Arai: Cell Pinball: Phenomenon and Mechanism of Inertia-Like Cell Motion in a Microfluidic Channel, Lab on a Chip, vol.15, pp3307-3313, 2015 (SCI, IF=6.045)  Highlighted on Lab on a Chip blog video link
  8. T. Monzawa, M. Kaneko, C. D. Tsai*, S. Sakuma and F. Arai: On-Chip Actuation Transmitter for Enhancing the Dynamic Response of Cell Manipulation using a Macro-scale Pump, Biomicrofluidics, vol.9, no.1, 014114, 2015 (SCI, IF=2.535)  link
  9. C. D. Tsai*, S. Sakuma, F. Arai, T. Taniguchi, T. Ohtani, Y. Sakata and M. Kaneko: Geometrical Alignment for Improving Cell Evaluation in a Microchannel with Application on Multiple Myeloma Red Blood Cells, RSC Advances, vol.4, no.85, pp45050-45058, 2014 (SCI, IF=3.108)  link
  10. C. D. Tsai*, S. Sakuma, F. Arai and M. Kaneko: A New Dimensionless Index for Evaluating Cell Stiffness-based Deformability in Microchannel, IEEE Transactions on Biomedical Engineering, vol.61, no.4, pp1187-1195, 2014 (SCI, IF=3.577)  link
  11. S. Sakuma*, K. Kuroda, C. D. Tsai, W. Fukui, F. Arai and M. Kaneko: Red Blood Cell Fatigue Evaluation based on the Close-encountering Point between Extensibility and Recoverability, Lab on a Chip, vol.14, no.6, pp1135-1141, 2014 (SCI, IF=6.045)  link
  12. C. D. Tsai, I. Kao*, M. Higashimori, and M. Kaneko: Modeling, Sensing, and Interpretation of Viscoelastic Contact Interface, Advanced Robotics, vol. 26, no. 11-12, pp1393-1418, 2012. (SCI, IF=0.516)  link
  13. I. G. Ramirez-Alpizar, M. Higashimori*, M. Kaneko, C. D. Tsai, and I. Kao: Dynamic Nonprehensile Manipulation for Rotating a Thin Deformable Object: an Analogy to Bipedal Gaits, IEEE Transactions on Robotics, vol.28, no.3, pp607-618, 2012 . (SCI, IF=4.036)  link
  14. I. Kao*, X. Li and C. D. Tsai: Model-Based and Wavelet-Based Fault Detection and Diagnosis for Biomedical and Manufacturing Applications: Leading Towards Better Quality of Life, Smart Structures and Systems, vol. 5, no. 2, pp153-171, 2009. (SCI, IF=1.382)  link

Proceedings in International Conferences (Peer-Reviewed):    *corresponding author
      2017  

  1. C. D. Tsai*, K. Teramura, K. Mizoue and M. Kaneko: 3000 Hz Cell Manipulation in a Microfluidic Channel, IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS2017), (Vancouver, Canada, 2017.10), Accepted.   conf.  
  2. M. Kaneko, T. Ishida, C. D. Tsai*, H. Ito, M. Chimura, T. Taniguchi, T. Ohtani and Y. Sakata: On-Chip RBC Deformability Checker Embedded with Vision Analyzer, IEEE International Conference on Mechatronics and Automation (ICMA2017), (Takamatsu, Japan, 2017.8), Acceptedconf.  
  3. K. Mizoue, N. Yagyu, C. D. Tsai* and M. Kaneko: Hybrid Actuation for Long-Term Cell Manipulation in a Microfluidic Channel, IEEE International Conference on Advanced Intelligent Mechatronics (AIM2017), (Munich, Germany, 2017.07), Accepted.  conf.  
  4. C. D. Tsai*, T. Akai, M. Horade, H. Ito and M. Kaneko: Virtual Vortex Gear, The 19th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers2017), (Kaohsiung, Taiwan, 2017.06), pp583-586 oral presentation (21.7%).  conf.  
  5. C. D. Tsai* and M. Kaneko: Adjustable Gain for Steering Between High-Speed and High-Resolution Cell Manipulation, The 19th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers2017), (Kaohsiung, Taiwan, 2017.06), pp1762-1765.  conf.  
  6. H. Ito*, R. Murakami, C. D. Tsai, M. Horade, M. Tanaka and M. Kaneko: Red Blood Cell Deformability upon Continuous or Repetitive Loadings, The 30th IEEE Conference on Micro Electro Mechanical Systems (MEMS2017), (Las Vegas, USA, 2017.01), pp141-144. oral presentation (9.8%).  conf.
  7. R. Murakami, A. Yamamoto, H. Ito, C. D. Tsai, M. Horade, M. Tanaka and M. Kaneko*: Observation of Cell Pinball Through High Speed Switching Between Reflection Interference and Phase Contrast, The 30th IEEE Conference on Micro Electro Mechanical Systems (MEMS2017), (Las Vegas, USA, 2017.01), pp1337-1338.  conf.
  8. M. Horade*, M. Kaneko, C. D. Tsai, H. Ito, N. Higashino, T. Akai, U. Yokoyma, Y. Ishikawa, S. Sakuma and F. Arai: On-Chip Cell Gym, The 30th IEEE Conference on Micro Electro Mechanical Systems (MEMS2017), (Las Vegas, USA, 2017.01), pp603-604.  conf.

  9.   2016  

  10. C. D. Tsai*, M.H. Phan and M. Kaneko: Buckling of RBC under Positive and Negative Driving Pressure in a Microchannel, The 27th International Symposium on Micro-Nano Mechatronics and Human Science (MHS2016), (Nagoya, Japan, 2016.11), pp122-122.  conf.  link
  11. C. D. Tsai*, M.H. Phan, K. Mizoue and M. Kaneko: Unexpected Beads Alignment in a Microfluidic Channel, IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS2016), (Daejeon, Korea, 2016.10), pp5143-5148.  conf.  link
  12. C. D. Tsai* and M. Kaneko: Cell Sweeper for Microfluidic Cavity, The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS16), (Dublin, Ireland, 2016.10), pp1537-1538.  conf.
  13. M. Horade*, C. D. Tsai, H. Ito, M. Tanaka and M. Kaneko: "Chameleon Effect'' of RBC Under Loading in Microfluidic Channel, The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS16), (Dublin, Ireland, 2016.10), pp311-312.  conf.
  14. C. D. Tsai*, M. Horade, H. Ito, M. Tanaka and M. Kaneko: High-Resolution Cell Manipulation for Longstanding Load on Red Blood Cells, IEEE International Conference on Mechatronics and Automation (ICMA2016), (Harbin, China, 2016.8), pp914-919.  conf.  link
  15. R. Murakami, C. D. Tsai*, H. Ito, M. Tanaka, S. Sakuma, F. Arai and M. Kaneko: Catch, Load and Launch toward On-Chip Active Cell Evaluation, IEEE International Conference on Robotics and Automation (ICRA2016), (Stockholm, Sweden, 2016.5), pp1713-1718.  link

  16.   2015  

  17. C. D. Tsai* and M. Kaneko: Frequency Responses of On-Chip Pressure Sensor with Different Deformation Chambers, The 26th International Symposium on Micro-Nano Mechatronics and Human Science (MHS2015), (Nagoya, Japan, 2015.11), pp292-293.  conf.  link
  18. C. D. Tsai* and M. Kaneko: Pressure Transmitter for Local Pressure Sensing in a Microchannel, The 9th IEEE International Conference on Nano/Molecular Medicine and Engineering (NANOMED2015), (Waikiki, Hawaii, USA, 2015.11), pp19-22.  conf.  link
  19. C. D. Tsai* and M. Kaneko: On-Chip Micro Manometer, The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS15), (Gyeongju, Korea, 2015.10), pp1879-1881.  conf.
  20. C. D. Tsai*, T. Nakamura and M. Kaneko: An On-Chip, Electricity-Free and Single-Layer Pressure Sensor for Microfluidic Applications, IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS2015), (Hamburg, Germany, 2015.9-10), pp165-170.  conf.  link
  21. C. D. Tsai*, K. Mizoue, M. Kaneko, S. Sakuma and F. Arai: Novel Microfluidic Chip for Extracting Cell Deformability, IEEE International Conference on Mechatronics and Automation (ICMA2015), (Beijing, China, 2015.8), pp2139-2144.  conf. link
  22. Frederike Hesse, C. D. Tsai* and M. Kaneko: Characteristics of Vision-Based On-Chip Pressure Sensor with Different Concentrations of Sensing Fluid, IEEE International Conference on Mechatronics and Automation (ICMA2015), (Beijing, China, 2015.8), pp517-522.Toshio Fukuda Best Award in Mechatronics  conf. link
  23. C. D. Tsai* and M. Kaneko: On-Chip Pressure Sensing by Visualizing PDMS Deformation using Microbeads, The 28th IEEE Conference on Micro Electro Mechanical Systems (MEMS2015), (Estoril, Portugal, 2015.01), pp722-725.  conf. link

  24.   2014  

  25. C. D. Tsai*, M. Kaneko and F. Arai: Improving the Evaluation of Cell Deformability by Different Channel Width in a Microfluidic Device, The 11th International Conference on Ubiquitous Robots and Ambient Intelligence (URAI2014), (Kuala Lumpur, Malaysia, 2014.11), pp522-524.  conf. link
  26. C. D. Tsai*, S. Sakuma, F. Arai and M. Kaneko: What is the Difference of Cell Deformation between PUSH and PULL?, The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2014), (San Antonio, USA, 2014.10), pp793-795.  conf.
  27. C. D. Tsai* and M. Kaneko: Evaluating RBC Deformability in a Microchannel under Mannitol Adenine Phosphate, SICE Annual Conference (SICE2014), (Sapporo, Japan, 2014.9), pp1474-1477.  conf.

  28.   2013  

  29. C. D. Tsai*, S. Yoshikawa, S. Sakuma, F. Arai and M. Kaneko: Image-Based Screening for Erythrocyte Characteristics of Patients Receiving Dialysis Service, ASN Kidney Week 2013 Annual Meeting, (Atlanta, USA, 2013.11), pp128A.  conf.
  30. S. Yoshikawa, C. D. Tsai, S. Sakuma, F. Arai and M. Kaneko*: Realtime Cell Tracking in a Microchannel, The 10th International Conference on Ubiquitous Robots and Ambient Intelligence (URAI2013), (Jeju, Korea, 2013.11), pp144-147.  link
  31. C. D. Tsai*, S. Sakuma, M. Kaneko and F. Arai: Normalization of Flow-in Velocity for Improving the Evaluation on Cell Deformability, IEEE International Conference on Mechatronics and Automation (ICMA2013), (Takamatsu, Japan, 2013.8), pp261-266.  link
  32. C. D. Tsai*, M. Kaneko, S. Sakuma and F. Arai: Distinct Patterns of Cell Motion inside a Micro-Channel under Different Osmotic Conditions, The 35th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC2013), (Osaka, Japan, 2013.7), pp5525-5528.  link
  33. C. D. Tsai*, M. Kaneko, S. Sakuma and F. Arai: Observability of Cell Stiffness in Micro-Channel Method, IEEE International Conference on Robotics and Automation (ICRA2013), (Karlsruhe, Germany, 2013.5), pp2792-2798.  link

  34.   2012  

  35. C. D. Tsai*, M. Kaneko, S. Sakuma and F. Arai: Biomechanical Properties of Red Blood Cell through the Motion inside a Micro-channel, The 23rd International Symposium on Micro-Nano Mechatronics and Human Science (MHS2012), (Nagoya, Japan, 2012.11), pp390-392.  link
  36. C. D. Tsai*, M. Kaneko and F. Arai: Enhanced Cell Stiffness Evaluation by Two-Phase Decomposition, The 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2012), (Okinawa, Japan, 2012.10), pp1009-1011.  conf.
  37. C. D. Tsai*, M. Kaneko and F. Arai: Evaluation of Cell Impedance Using a μ-channel, The 34th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC2012), (San Diego, USA, 2012.8), pp5518-5521.  link
  38. C. D. Tsai*, M. Kaneko, S. Sakuma and F. Arai: Phase Decomposition of a Cell Passing Through a μ-channel: A Method for Improving the Evaluation of Cell Stiffness, IEEE International Conference on Mechatronics and Automation (ICMA2012), (Chengdu, China, 2012.8), pp138-143. Best Paper Award in Automation  link

  39.   2011  

  40. I. G. Ramirez-Alpizar, M. Higashimori*, M. Kaneko, C. D. Tsai, and I. Kao: Nonprehensile Dynamic Manipulation of a Sheet-like Viscoelastic Object, IEEE International Conference on Robotics and Automation (ICRA2011), (Shanghai, China, 2011.5), pp5103-5108.  link
  41. J. Nishiyama, C. D. Tsai, M. Quigley, I. Kao*, A. Shibata, M. Higashimori, and M. Kaneko: An Experimental Study of Biologically Inspired Artificial Skin Sensor Under Static Loading and Dynamic Stimuli, IEEE International Conference on Robotics and Automation (ICRA2011), (Shanghai, China, 2011.5), pp1778-1783.  link

  42.   2010  

  43. C. D. Tsai, I. Kao*, A. Shibata, K. Yoshimoto, M. Higashimori, and M. Kaneko: Experimental Study of Creep Response of Viscoelastic Contact Interface Under Force Control, IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS2010), (Taipei, Taiwan, 2010.10.20), pp4257-4280.  link
  44. C. D. Tsai, J. Nishiyama, I. Kao*, M. Higashimori, and M. Kaneko: Study of the Relationship Between the Strain and Strain Rate for Viscoelastic Contact Interface in Robotic Grasping, IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS2010), (Taipei, Taiwan, 2010.10.19), pp592-597.  link

  45.   2009  

  46. C. D. Tsai, I. Kao*, K. Yoshimoto, M. Higashimori, and M. Kaneko: An Experimental Study and Modeling of Loading and Unloading of Nonlinear Viscoelastic Contacts, IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS2009), (St. Louis, MO, USA, 2009.10.13), pp3404-3409.  link
  47. C. D. Tsai, and I. Kao*: The Latency Model for Viscoelastic Contact Interface in Robotics: Theory and Experiments, IEEE International Conference on Robotics and Automation (ICRA2009), (Kobe, Japan, 2009.5.15), pp1291-1296.  link

  48.   2008  

  49. C. D. Tsai, I. Kao*, N. Sakamoto, M. Higashimori, and M. Kaneko: Applying Viscoelastic Contact Modeling to Grasping Task: an experimental case study, IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS2008), (Nice, France, 2008.9.24), pp1790-1795.  link

Grants and Awards  to top

Principal Investigator, JSPS KAKENHI Grant#16K18051, On-Chip Cell Impedance Evaluator, 2016/4 - 2018/3.
Principal Investigator, JSPS KAKENHI Grant#26820086, Enhanced Cell Evaluation by Phase Decomposition, 2014/4 - 2016/3.
Toshio Fukuda Best Award in Mechatronics, IEEE International Conference on Mechatronics and Automation, 2015.
Outstanding Poster Presenting Award, The 4th Young Scientist Symposium of Hyper Bio Assembler for 3D Cellular Innovation, 2015.
Best Paper Award in Automation, IEEE International Conference on Mechatronics and Automation, 2012.
Scholarship and Tuition Wavier, The State University of New York (SUNY) at Stony Brook, 2006-2010.


Activities and Services  to top

Service on International Journals:
      Editor, ROBOMECH Journal, Springer (link)
      Associate Editor, IEEE Robotics and Automation Letters (link)
      Reviewer, IEEE Transactions on Systems, Man, and Cybernetics
      Reviewer, IEEE Transactions on Haptics
      Reviewer, Micromachines
      Reviewer, Smart Materials and Structures
      Reviewer, Advanced Robotics
      Reviewer, ROBOMECH Journal
      Reviewer, Journal of Robotics & Mechatronics
      Reviewer, Micro and Nanosystems
      Reviewer, Intelligent Service Robotics
Service on International Conferences:
      Editor, IEEE/RSJ International Conf. of Intelligent Robots and Systems (IROS), 2017.
      Associate Editor, IEEE/RSJ International Conf. of Intelligent Robots and Systems (IROS), 2013, 2014.
      Conference Secretariat, IEEE/RSJ International Conf. of Intelligent Robots and Systems (IROS), 2013.
      Reviewer, IEEE International Conf. on Robotics and Automation (ICRA), 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017.
      Reviewer, IEEE/RSJ International Conf. of Intelligent Robots and Systems (IROS), 2011, 2012, 2015, 2016.
      Reviewer, IEEE International Conf. of Automation Science and Engineering (CASE), 2014, 2015, 2016.
      Reviewer, IEEE/ASME International Conference on Advanced Intelligent Mechatronics (AIM), 2014, 2017.
      Reviewer, IEEE International Conf. on Biomedical Robotics and Biomechatronics (BioRob), 2010, 2012.
      Session Chair, "Biomedical Technology" in ICMA2015.
      Session Chair, "Biological and Physiological Engineering" in SICE2014.
      Session Chair, "Teleoperation for Medical Robotics", "Visual Servo II" and "SLAM IV" in IROS2013.
Service on Other Reviews:
      Reviewer, Research Grants Council of Hong Kong
      Reviewer, Springer Handbook of Robotics
Invited Talk:
      Civic Scientist Lecture, Osaka University Nakanoshima Center, Osaka, Japan, 2016-12-10. news snapshot
      Dept. Seminar, Dept. of Mechanical Eng., National Taiwan University of Science and Technology, Taipei, Taiwan, 2016-05-06.
      Dept. Seminar, Dept. of Mechanical Eng., Stony Brook University, Stony Brook, USA, 2015-03-13.
      The 6th Meijo Science Technology Seminar, Meijo University, Nagoya, Japan, 2015-02-23.
      The Workshop of ``Hyper Bio Assembler for 3D Cellular System Innovation" in the IROS2013, Tokyo, Japan, 2013-11-03.
Member of IEEE Robotics and Automation Society (IEEE RAS) since 2009


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