Non-equilibrium interfacial phenomena as physics of biological soft interfaces,
Structure and function of soft interfaces in meso-scale,
Soft matter physics, Biophysics,
Physics of diseases, Medical application,
Control engineering, Robotics
Physics of non-equilibrium interfacial phenomena,
crossing the hierarchical complexity
Biological interfaces not only divide the inner and outer worlds for living matters, but also play complex roles by consuming energy under a fluctuating environment. What functions and how much complexity are necessary to be "living"? What principles of what materials govern those living phenomena? I am trying to better understand the living interfacial phenomena from the viewpoint of physics, which can tackle the essential principles of materials.
Precise control for extracting characteristics of living matters
Living matters have individuality in their behaviors and responses. I am trying to extract the essential aspects of living systems, including the individuality, through the experiments based on precise controls and measurements, utilizing cutting-edge microfluidics and robotics.
"LED-CT scan for pH distribution on a cross-section of cell culture medium"
Nobuya Higashino, Toshio Takayama, Hiroaki Ito, Mitsuhiro Horade, Yasutaka Yamaguchi, Chia-Hung Dylan Tsai, and Makoto Kaneko
Sensors, 18, 191:1-10 (2018) / Full text (ResearchGate)
"Adsorption of galloyl catechin aggregates significantly modulates membrane mechanics in absence of biochemical cues"
Takahisa Matsuzaki, Hiroaki Ito, Veronika Chevyreva, Ali Makky, Stefan Kaufmann, Kazuki Okano, Naritaka Kobayashi, Masami Suganuma, Seiichiro Nakabayashi, Hiroshi Y. Yoshikawa, and Motomu Tanaka
Phys. Chem. Chem. Phys., 19, 19937-19947 (2017) / Full text (ResearchGate)
"Red blood cell responses during a long-standing load in a microfluidic constriction"
Mitsuhiro Horade, Chia-Hung Dylan Tsai, Hiroaki Ito, and Makoto Kaneko
Micromachines, 8, 100:1-10 (2017) / Full text (ResearchGate)
"Mechanical diagnosis of human erythrocytes by ultra-high speed manipulation unraveled critical time window for global cytoskeletal remodeling"
Hiroaki Ito, Ryo Murakami, Shinya Sakuma, Chia-Hung Dylan Tsai, Thomas Gutsmann, Klaus Brandenburg, Johannes M. B. Pöschl, Fumihito Arai, Makoto Kaneko, and Motomu Tanaka
Sci. Rep., 7, 43134:1-14 (2017) / Full text (ResearchGate)
Press Release: Osaka University / Kyoto University / NIKKEI / NIKKEISANGYOU (28.02.2017)/ mynavi NEWS / EurekAlert! (in English) / MedicalXpress (in English) / AlphaGalileo (in English)
"Coarse-grained molecular dynamics simulation of binary charged lipid membranes: Phase separation and morphological dynamics"
Hiroaki Ito, Yuji Higuchi, and Naofumi Shimokawa
Phys. Rev. E, 94, 042611:1-11 (2016) / arXiv:1607.06167 / Full text (ResearchGate)
"An on-chip RBC deformability checker significantly improves velocity-deformation correlation"
Chia-Hung Dylan Tsai, Junichi Tanaka, Makoto Kaneko, Mitsuhiro Horade, Hiroaki Ito, Tatsunori Taniguchi, Tomohito Ohtani, and Yasushi Sakata
Micromachines, 7, 176:1-13 (2016) / Full text (ResearchGate)
Press Release: Osaka University / Yomiuri Online / JIJI.COM
"Tracking mechanical and morphological dynamics of regenerating hydra tissue fragments using a two fingered micro-robotic hand"
Mariam Veschgini, Florian Gebert, Nyamdorj Khangai, Hiroaki Ito, Ryo Suzuki, Thomas W. Holstein, Yasushi Mae, Tasuo Arai, and Motomu Tanaka (equally contributed)
Appl. Phys. Lett., 108, 103702:1-4 (2016) / Full text (ResearchGate)
"Non-periodic oscillatory deformation of an actomyosin microdroplet encapsulated within a lipid interface"
Yukinori Nishigami, Hiroaki Ito, Seiji Sonobe, and Masatoshi Ichikawa (equally contributed)
Sci. Rep., 6, 18964:1-11 (2016) / Full text (ResearchGate)
"Coupling between pore formation and phase separation in charged lipid membranes"
Hiroki Himeno, Hiroaki Ito, Yuji Higuchi, Tsutomu Hamada, Naofumi Shimokawa, and Masahiro Takagi
Phys. Rev. E, 92, 062713:1-12 (2015) / arXiv:1504.06039 / Full text (ResearchGate)
"Wrinkling of a spherical lipid interface induced by actomyosin cortex"
Hiroaki Ito, Yukinori Nishigami, Seiji Sonobe, and Masatoshi Ichikawa (equally contributed)
Phys. Rev. E, 92, 062711:1-8 (2015) / arXiv:1505.04371 / Full text (ResearchGate)
"Droplet-Shooting and Size-Filtration (DSSF) Method for Synthesis of Cell-Sized Liposomes with Controlled Lipid Compositions"
Masamune Morita, Hiroaki Onoe, Miho Yanagisawa, Hiroaki Ito, Masatoshi Ichikawa, Kei Fujiwara, Hirohide Saito, and Masahiro Takinoue
ChemBioChem, 16, 2029-2035 (2015)
"Quantification of the influence of endotoxins on the mechanics of adult and neonatal red blood cells"
Hiroaki Ito, Navina Kuss, Bastian E. Rapp, Masatoshi Ichikawa, Thomas Gutsmann, Klaus Brandenburg, Johannes M. B. Pöschl, and Motomu Tanaka
J. Phys. Chem. B, 119, 7837-7845 (2015) / Full text (ResearchGate)
"Dynamical formation of lipid bilayer vesicles from lipid-coated droplets across a planar monolayer at an oil/water interface"
Hiroaki Ito, Toru Yamanaka, Shou Kato, Tsutomu Hamada, Masahiro Takagi, Masatoshi Ichikawa, and Kenichi Yoshikawa
Soft Matter, 9, 9539-9547 (2013) / Full text (ResearchGate)
Selected as Journal Front Cover
Highlighted as September's Hot Papers in RSC publishing blog and 2013 Hot Papers
"Emergence of a thread-like pattern with charged phospholipids on an oil/water interface"
Hiroaki Ito, Miho Yanagisawa, Masatoshi Ichikawa, and Kenichi Yoshikawa
J. Chem. Phys., 136, 204903:1-6 (2012) / Full text (ResearchGate)
Selected as JCP Editor’s Choice for 2012
"Integration of fluctuation spectroscopy into a microfluidic platform for novel cellular viscoelastic measurement"
Hiroaki Ito, Chia-Hung Dylan Tsai, and Makoto Kaneko
The 31st IEEE International Conference on Micro Electro Mechanical Systems (MEMS2018, Belfast, UK), Oral (acceptance rate 10.0%), 137-140 (2018)
"Measurement of both viscous and elastic constants of a red blood cell in a microchannel"
Atsushi Kirimoto, Hiroaki Ito, Chia-Hung Dylan Tsai, and Makoto Kaneko
The 31st IEEE International Conference on Micro Electro Mechanical Systems (MEMS2018, Belfast, UK), Poster, 388-391 (2018)
"Pressure dependency of virtual vortex gear"
Toshio Takayama, Chia-Hung Dylan Tsai, Hiroaki Ito, and Makoto Kaneko
The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2017, Savannah, USA), in press
"Red blood cell deformability in patients with heart failure"
Misato Chimura, Tomohito Ohtani, Tatsunori Taniguchi, Takuto Ishida, Junnichi Tanaka, Hiroaki Ito, Yasumasa Tsukamoto, Makoto Kaneko, and Yasushi Sakata
J. Card. Fail. (in The 21st Annual Scientific Meeting of the Japanese Heart Failure Society) (Akita, Japan), Oral, S31 (2017)
"On-Chip RBC deformability checker embedded with vision analyzer"
Makoto Kaneko, Takuto Ishida, Chia-Hung Dylan Tsai, Hiroaki Ito, Misato Chimura, Tatsunori Taniguchi, Tomohito Ohtani, and Yasushi Sakata
IEEE International Conference on Mechatronics and Automation (ICMA2017, Takamatsu, Japan), Oral, 2005-2010 (2017)
"Virtual vortex gear"
Chia-Hung Dylan Tsai, Takayuki Akai, Mitsuhiro Horade, Hiroaki Ito, and Makoto Kaneko
The 19th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers2017, Kaohsiung, Taiwan), Oral (acceptance rate 21.7%), Oral, 583-586 (2017)
"Red blood cell deformability upon continuous or repetitive loadings"
Hiroaki Ito, Ryo Murakami, Chia-Hung Dylan Tsai, Mitsuhiro Horade, Motomu Tanaka, and Makoto Kaneko
The 30th IEEE International Conference on Micro Electro Mechanical Systems (MEMS2017, Las Vegas, USA), Oral (acceptance rate 9.8%), 141-144 (2017)
"Observation of cell pinball through high speed switching between reflection interference and phase contrast"
Ryo Murakami, A. Yamamoto, Hiroaki Ito, Chia-Hung Dylan Tsai, Mitsuhiro Horade, Motomu Tanaka, and Makoto Kaneko
The 30th IEEE International Conference on Micro Electro Mechanical Systems (MEMS2017, Las Vegas, USA), Poster, 1337-1338 (2017)
"On-chip cell gym"
Mitsuhiro Horade, Makoto Kaneko, Chia-Hung Dylan Tsai, Hiroaki Ito, Nobuya Higashino, Takayuki Akai, Utako Yokoyama, Yoshihiro Ishikawa, Shinya Sakuma, and Fumihito Arai
The 30th IEEE International Conference on Micro Electro Mechanical Systems (MEMS2017, Las Vegas, USA), Poster, 603-604 (2017)
""Chameleon Effect" of RBC Under Loading in Microfluidic Channel"
Mitsuhiro Horade, Chia-Hung Dylan Tsai, Hiroaki Ito, Motomu Tanaka, and Makoto Kaneko
The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2016, Dublin, Ireland), Poster, 311-312 (2016)
"High-Resolution Cell Manipulation for Longstanding Load on Red Blood Cells"
Chia-Hung Dylan Tsai, Mitsuhiro Horade, Hiroaki Ito, Motomu Tanaka, and Makoto Kaneko
IEEE International Conference on Mechatronics and Automation (ICMA2016, Harbin, China), Poster, 914-919 (2016)
"Catch, Load and Launch toward On-Chip Active Cell Evaluation"
Ryo Murakami, Chia-Hung Dylan Tsai, Hiroaki Ito, Motomu Tanaka, Shinya Sakuma, Fumihito Arai, and Makoto Kaneko
2016 IEEE International Conference on Robotics and Automation (ICRA2016, Stockholm, Sweden), Poster, TuDaT3.4, 1713-1718 (2016)
"Active materials integrated with actomyosin"
Hiroaki Ito, Masahiro Makuta, Yukinori Nishigami, and Masatoshi Ichikawa
J. Phys. Soc. Jpn., 86, 101001:1-6 (2017)
"Mechanism of bleb-driven amoeboid locomotion"
Yukinori Nishigami, Hiroaki Ito, and Masatoshi Ichikawa
Jpn. J. Protozool, 49, (2016) (in Japanese)
"Studies on bleb-driven cell locomotion using reconstituted systems"
Yukinori Nishigami, Hiroaki Ito, and Masatoshi Ichikawa
植物科学の最前線 (BSJ-Review), 6, 82-91 (2015) (in Japanese)
日本数理生物学会ニュースレター, 64, 3 (2011) (in Japanese)
時空間秩序・生命物理科学研究会（同志社びわこトリートセンター）、2017.03.04 (in Japanese)
非線形ソフトマター研究会2016（横浜市民ふれあいの里）、2016.10.29 (in Japanese)
Approach to self-propelled artificial cells from microdroplets
Symposium on The 53rd Annual Meeting of the Biophysical Society of Japan, 15.09.2015
||MEMS2018 Young Researcher Travel Grant
|07.2017 - 03.2019
||JSPS KAKENHI Challenging Research (Pioneering)
|08.2016 - 03.2018
||Grant-in-Aid for Research Activity Start-up (JSPS) (completed by 07.2017)
|04.2016 - 03.2017
||Sasakawa Scientific Research Grant, The Japan Science Society
|04.2013 - 03.2016
||Grants-in-Aid for the Japan Society for the Promotion of Science (JSPS) Research Fellowship for Young Scientists (DC1)
|2011.07 - 2012.03
||Kyoto University Venture Business Laboratory (grants-in-aid program for young reserachers)
|Robotics and Mechatronics Division, Certificate of Merit for ROBOMECH Outstanding Research Activity, The Robotics and Mechatronics Conference 2017 (ROBOMECH2017)|
|Best Poster Award, 4th Kyoto Young Researchers Workshop on Softmatter|
Affiliated academic organizations
|03.2007 - 03.2011
||Faculty of Science, Kyoto University
|04.2011 - 03.2013
||Department of Physics, Graduate School of Science, Kyoto University (MC)
|    08.2012 - 10.2012
||    Curie Institute, France
|04.2013 - 03.2016
||Department of Physics, Graduate School of Science, Kyoto University (DC), Ph.D (Science)
||JSPS Research Fellowship for Young Scientists (DC1)
|    12.2013 - 02.2014
||    University of Heidelberg, Germany（Externally supervised）
|    09.2014 - 10.2014
||    University of Heidelberg, Germany
|04.2016 - 03.2018
||Department of Mechanical Engineering, Graduate School of Engineering, Osaka University, Postdoctral Fellow
|03.2018 - present
||JSPS Research Fellow (PD) / Visiting Researher at Osaka University
Yamadaoka 2-1, Suita, Osaka
M4-406, Osaka University